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Pentosan polysulfate sodium for cartilage

Can you do a deep dive on cartilage regeneration using pentosan polysulfate sodium (a peptide)? There's some controversy because it might also cause a rare eye disease. But I'm desperate to fix my ankle cartilage problem...

Peptide bioregulators Vladimir Khavinson

There's a class of peptides (not really peptides but "bioregulators") that came out of the Saint Petersburg Institute, called "bioregulators". These bioregulators are (supposedly) a cure for all sorts of things. They were discovered by Vladimir Khavinson, a (seemingly legit) scientist from Russia, and have been around for decades in Russia, going back to the Soviet age. The company claims that these bioregulators are safe and have been tested in clinical trials (in Russia). I've tracked some studies on PubMed but I do not have sufficient scientific skill to assess what the studies are worth. Some of the more "famous" peptide bioregulators are epithalon, cerluten, and sigumir.

Honey

The benefits and potential risks of honey - ingesting as well as on the skin

What causes sadness?

We recently had to put my dog down. I was naturally very upset but it was more of a dull ache but every so often right before and immediately after I’d get those sudden and intense moments where it felt painful and couldn’t actual control my self. It got me thinking about the mechanisms behind sadness and all I could really find when I attempted to research sadness were papers and information on people with depression. I’m more interested in the temporary sadness we all feel every so often and how it has such a powerful effect.

Supplement stack to combat osteoarthritis

Could you do a deep dive on osteoarthritis? In the first place I am interested in the efficacy and safety of supplements to combat osteoarthritis. I am currently taking 1350 mg of EPA and 300 mg of DHA/day, MSM (a sulfate), boswellia serrata, chondroitin, glucosamine and collagen. Is there anything else that could be helpful? Any concerns?