The body and homeostasis - In relation to supplementation & optimisation
I see there is another question around Homeostasis. My question differs slightly with a bit more context. I am completely new toto biology, but i do understand the concept of homeostasis having studied systems theory with the context of management. As i understand it, the body is a set of of homeostatic systems, which regulate and modulate various functions. Some things are regulated and modulated within a very thight band (i.e Body Temperature) where as others have a much larger range. As i understand regulatory systems (homeostatsis) an excess of something that is out of range would cause the body to regulatory system to kick in and bring it back within a specific range. Examples: Too Hot and we Sweat, Too Cold and we Shiver There is another implication to this (as i understand it) in relation to supplementation, and other attempts to optimise health. Given exogenous supplements for something that the body can produce itself, would it make it more likely that the body DOWN Regulates the production of the same thing? My understanding (which could be flawed) this is the reason why exogenous hormones such as testosterone can be problematic. So the questions: 1. Could you discuss some of the core mechanisms and homeostatic systems within the human body 2. Which of these systems are highly critical - In all likely hood there are probably 100's. My question are those related to sports performance, and longevity and general well being 3. How can we differentiate between compounds and/or supplements that may affect the bodies own internal systems (i.e Leading to downregulation, or having downstream effects). 4. Which of these systems are really dangerous to mess with - i.e We should be threading very lightly, ensuring we have enough evidence of safety, efficacy and the right dosages
What are the concerns with Long-term Anastrozole
Hi Dr. Huberman, I'm 40 and have been doing TRT, 0.5 mg/week under medical supervision, for a few years. It has helped with recovery quite a lot, but now I'm concerned about the long-term effects of taking anastrozole. I've been prescribed 0.5mg/week of Anastrozole, which has kept my estradiol levels in the high 30's. I've recently been reducing my dose of T to 0.2mg twice a week and may continue reducing even more as my Free T levels are still very strong at a 20% reduction, and I have noticed no real effect on my ability to recover from workouts. I'm open to weaning off entirely, but I can no longer get HCG to help with that transition. What information can you offer to help me make a good decision? Than you kindly, James
women's health after 60
Thanks for having Dr. Sara Gottfried on today to discuss women's health! I was left wondering if there's anything a woman could do in her 60's or after menopause, who didn't take hormone replacement in perimenopause? I'm 60 and was never given the option unfortunately to take hormone replacement during perimenopause and now am concerned about the cognitive declines associated with female aging! Any thoughts Dr. Huberman? Thanks in advance!