A regimen for maximizing positive effects of glp-1s
Hi Andrew After hearing your conversation with Dr. Craig Koniver, who advocates micro-dosing tirzepatide to balance effectiveness with minimal side effects, I'm currently exploring a similar low-dose regimen (around 1.5–2 mg/week) primarily to manage appetite and cravings. Could combining this micro-dose GLP-1 strategy with enhanced cellular communication methods—like NAD+ supplementation or targeted peptides—and adding cold therapy to stimulate the conversion of white adipose tissue into beige or brown fat, lead to synergistic metabolic improvements for obese individuals? I'd appreciate your perspective on potential benefits, cautions, or further optimizations of this multifaceted approach. Of the things you'd recommend, I suspect many of the strategies are useful beyond the time that you've lost your desired amount of weight. I think LOTs of people would benefit from your insight on a long term approach to getting to healthy weight when you're an older adult and mobility is harder (knees/hips etc). I wish we could get Irisin in a bottle! Thanks for all your information youv'e been providing. I really enjoy learning from you and your guests.
Hi Andy, Any updates on the squirrel you saved a few days ago???? It's a serious inquiry. I'm an environmental advocate and love animals and was geniunly happy that you saved the baby squirrel. But never heard back if he woke up back 🤙🏽 Appreciate all your work
Hi Andy, Any updates on the squirrel you saved a few days ago???? It's a serious inquiry. I'm an environmental advocate and love animals and was geniunly happy that you saved the baby squirrel. But never heard back if he woke up back 🤙🏽 Appreciate all your work
Visual perception and time perception relationship.
I’ve heard you explain the relationship between visual perception by way of frame rates and how time perception affects it, and I’m fascinated with that! What I’m struggling with is this: during states of heightened arousal, the pupil dilation increases the perceived frame rate, allowing us to perceive more details, yet the brain continues to filter out certain visual information, such as motion blur or other anomalies, for the sake of efficiency. So we still miss a lot of input even when we’re dialed in and time feels like it’s going slow, is this correct? How can we potentially overcome this filtering process or train the brain to allow more of the full perceptual experience to reach conscious awareness ( without drugs :) Do we need to be in a both relaxation (time feels fast) and alertness (time feels slow) to get the most access to unfiltered information? I read The Secret Pulse of Time and I’m also into Merleau-Ponty’s Eye and Mind. If you have any book recommendations on this subject I’d love to know them :) Thank you Dr. Huberman for the wealth of knowledge you share! We are lucky! Kindly, Fabia
NAD Podcast
I really enjoyed the podcast with Dr. Koniver. I am 62 and continue to suffer old age issues, not as sharp mentally, sleep, mobility and the list continues. You have really improved my sleep and my alcohol consumption has decreased significantly. Thank you for helping. The Pepitide & Hormone Therapies for Health, Performance & Longevity podcast peaked my curiosity. I would like to try NAD infusions. Can you give me roadmap to start? What do I look for in choosing the infusion? How to handle the nausea you mentioned? Do you start with the infusion or with a loading dose? Are the compound solutions Dr. Koniver available to purchase? I hope I made my request clear. Sorry, I haven’t interacted with a podcast before.
Brain abscess
About 3 years ago I developed abscess in my brain. It was quite a painful ordeal; I spent a little over a month in the hospital followed by another couple months at home with a picc line for antibiotics. I was listening to last week's episode about metabolism and it spurred some thoughts and questions. You mentioned that the axons extending from the hypothalemus to the pituitary then releases stimulating hormones into the bloodstream. I am also a functionhealth.com member so I am often checking levels. One area that is within range but very low is testostrone. I run, weight train , eat very clean and get between 8 and 9 hours of sleep a night. However, at my last eye exam I failed my peripheral vision test. I tried it several times and failed. I am wondering if the abscess perhaps damaged my pituitary which my would affect my peripheral and also the stimulating hormone release of testerone? My neurologist , after my last MRI and EEG , said my brain seems to be healing well. I did have 3 small seizures about 5 months after getting out of the hospital ( 2 for which I was aware as they were happening of but could not control). I am on Keppra for those and have had no issues since. Again, I was told, my brain is healing from the abscess. Is it possible for the pituitary to have been damaged and causing the low testosterone? Been really focused on neuroplasticity since the abscess and discovering your podcast. If it is possible, what can be done to improve the release hormones from the pituitary? Thank you.
I quit smoking and have gained 45 pounds.
I gained 45 pounds after quitting smoking after 30+years. I workout 45min daily and eat a lean meal plan made by my personal trainer. I've had normal labs and my thyroid is good too even on imaging...I do ultrasound for a living and students need practice. I have since started perimenopause as well. I don't take medication and drink a gallon of water a day. Prior to this weight gain I was successfully in losing 100 pounds with my trainer in still following. I have tried to lower my caloric intake however I'm at 1500-1600 daily calories and I'm sometimes hungry. I do weight training daily and add cardio 3-4 times a week. My dr suggest glp1 but I don't want to... side effects and all that. Plus I've been successful prior to quitting smoking. Help
TBI, Dizzy spells, Supraventricular Tachycardia and Paroxysmal Sympathetic Hyperactivity - fixed with Clomid
For 17 years I have had a problem where my heart rate jumps to 220+ for little things like the wind blowing, walking on sand or train horns. Little things set me off. Trying to take hot clothes out of the dryer, getting something out of the oven. For 17 years I kept getting kicked back and forth from cardiologists and neurologists where they gave me hundreds of different things that just made things worse. Nothing worked. I ended up buying a bunch of medical books after listening to your podcast for the past couple of years. I found a good family doctor that agreed to run tests and worked with me to find a fix instead of just slapping me on the back of the head and giving me a prescription for Nurtec or some experimental medication from Jamaica. Anyway, sorry about the long rant. I noticed that when I got dizzy I had a circle on my forehead. My wife checked my temperature and when I get dizzy my forehead drops to around 94 to 95 degrees fahrenheit. After reading through books on the vascular system and endocrinology I noticed that estrogen had a lot to do with that stuff. I had a test for Luteinizing Hormone and Follicle Stimulating Hormone done and Luteinizing hormone was almost nothing but everything else was normal. I ended up getting Clomiphene Citrate and within a few days the dizzy spells went away. My resting heart rate dropped from around 120bpm into the 80bpm range. For the first time in 17 years I am able to do things again. I can even ride a bicycle without getting dizzy. It's crazy how well that works. I guess my question is, why don't Neurologists check hormones and why does there appear to be no research on this? I can find one article on hypogonadism but nothing for the autonomic nervous system or tachycardia and Clomiphene Citrate. That stuff works like crazy. I would just like to understand how or why it works and possibly if there's anything being done. It might be in the Neuroendocrinology books, I couldn't convince my wife to let me get a $3,500 book set on it.
Sleep Cycles in Women
I have two questions :) 1) You often recommend a 24 hour sleep cycle that starts in the morning, and exposure to the sun earyl to produce cortisol etc. - what about people who have different cycles? Some people are more of a night owl, or peak during midday or in the efternoon. Is there a neurological difference? What makes some people more inclined to one sleep patter or another? 2) What is the impact of menstruation on the sleep cycle in women? How does it affect the neurological aspects? Assuming it has a significant aspect, as hormones are key factors in behavior, and significantly affect sleep. In general, many women report fatigue during PMS and into the cycle. That means they need more sleep during some weeks and less in others. So, how do you optimize the sleep cycle monthly rather on a 24 hours basis? I hope this makes sense and doesn't repeat previously asked questions. Thanks! Chen
NIH grants are frozen. Will you speak out?
I understand your reluctance to wade into politics, but some of what the new administration is doing directly impacts the scientific community that you are a part of. You may or may not agree with the actions of the Trump/ Musk team, but surely you don't support crippling our researchers. Your voice is important and would have an impact. I hope you will use it.
Do you know her ?
https://www.instagram.com/reel/C6OxCFYJaSK/?igsh=MXVsOHBxdzFndGFydw== I think you didn’t talk about this yet? What’s your thoughts? Why would she avoid fatigue? Because of muscle adaptación or to train the next day? She’s not a weightlifter either. Would love to dive into this!!
cold showers
I have been listening to your podcast since I had to recover from an abcess in my brain and had time off. Have enjoyed the thought provoking research and guest. Is there any new data on the physiological affect of a cold shower? I enjoy cold showers, in that it wakes me up. However, I get a lot of push back from collegues who only believe peer reviewed research in which the the results are based on large data samples and when the findings specifically relate to the claim. I have listened and relistened to your discussion with Dr. Susanna Soberg and while I realize that discussion did not emphasize that cold showers have the same results as longer cold exposure via a cold plunge, the physical responses from simply having cold skin seemed enough for me to continue to practice cold showers. I , possibly with naivity, think the research will eventually reveal measurable results. My other question for you is, how do you answer critics that say you are exagerating or extrapolating results to appy more broadly than the data supports? I ask because , I want to defend your suggestions for life changes that positively affect our overall bodily health. Thank you.
AEDP - Emotional coregulation and undoing aloneness !
I was wondering if you could have a quick look at this magnificient approach. The "Accelerated Experiential Dynamic Psychotherapy" by Dr Diana Fosha has opened beautiful therapeutic "doors" for me as a psychiatrist (and therapist) and I wonder why it is not know by now... I wish more patients knew about it! Thanks!
Dr. Diane Powell - Telepathy / Autism Studies
I've recently had my imagination captured by the Telepathy Tapes podcast. The ontological implications are astounding. The TT feature former Harvard scientist Dr. Diane Hennacy Powell and her studies of telepathic abilities within non-verbal autistic people. The experiments she's done so far seem rigorous to me, but I'd like perspectives from folks more qualified and capable to interpret her results. The anecdotal evidence is moving as well, at least to me. I think Dr. Powell could make for an incredible podcast guest! I'm so curious about her work and this topic now. Thanks very much, Nick