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Anxiety depressive

Hi Mr Huberman Could you please help me with this question: How does microbiota impact the brain in anxio-depressive disorders and how effective are the antidepressant drugs? Thank you for your answer

chronic obstructive pulmonary disease

How to treat early COPD in a young person with few symptoms? Does medication slow down lung deterioration? What about dementia risk associated with anticholinergic LAMA?

Mewing

Does mewing work?

Biphasic sleep seems better?

Sleeping 10 PM to 6 AM seems to be worse for my recovery than sleeping 10-2 AM followed up with 3 AM to 8 AM, for example. The latter yields longer sleep duration for me on a consistent basis. Should I wake myself up on purpose to help this biphasic pattern and hence overall sleep duration (sacrificing sleep continuity?) Whoop data suggests I should sleep beyond my usual 7-7:30 hours of sleep, and I try to do that, but can only accomplish the recommended 8-8:30 hours of sleep when sleep is biphasic, e.g when I wake up between 2-4 AM and sleep through the typical 5:30-6:30 wake up time and oneards to 8 AM. It seems that when I sleep "twice per night", my sleep is a bit deeper in the early morning hours and I am able to "sleep through" the "critical morning threshold" or typical wake up times of 5:30, 6, 6:30 Surely morning outsife noise has an effect. I respect Andrew Hubermann and Mathew Walker recommendations on caffeine (mostly no coffee unless before 9 AM approx and only on extra cranky days)

Ketamine infusions for chronic pain including low back pain and sciatica.

In your show regarding the benefits and risks of using ketamine infusions in a medical setting, you spoke about depression, PTSD and some other mental conditions that were difficult to treat. However, ketamine infusions are now being used to help for chronic pain, including low back pain and sciatica. Since it was not mentioned in the podcast, I was wondering if you could do a new one that focused exclusively on chronic pain. If you have work out there that's already addressed this issue, please direct me to it. Thank you