Mfgm phospholipids
Hello, I recently tried a supplement called Nutiani MFGM (milk fat globule membrane phospholipids), and honestly, I was surprised by the effect. I felt noticeably calmer under stress and sharper cognitively—very much in line with what they claim. From what I understand, MFGM is largely removed from milk during the homogenization process, which might explain why it’s not something we usually get much of in our diet. The problem is that I can’t seem to get access to this ingredient anymore, and I’m struggling to find a real alternative. I looked through your content and found discussions on phosphatidylserine, but as far as I understand, PS is only one component of MFGM, which includes several other phospholipids and bioactive compounds. I was wondering if you’re familiar with MFGM specifically, or if you know of any alternatives that might have similar cognitive or stress-modulating effects. Thanks a lot, and really appreciate your work.
Mfgm phospholipids
Hello, I recently tried a supplement called Nutiani MFGM (milk fat globule membrane phospholipids), and honestly, I was surprised by the effect. I felt noticeably calmer under stress and sharper cognitively—very much in line with what they claim. From what I understand, MFGM is largely removed from milk during the homogenization process, which might explain why it’s not something we usually get much of in our diet. The problem is that I can’t seem to get access to this ingredient anymore, and I’m struggling to find a real alternative. I looked through your content and found discussions on phosphatidylserine, but as far as I understand, PS is only one component of MFGM, which includes several other phospholipids and bioactive compounds. I was wondering if you’re familiar with MFGM specifically, or if you know of any alternatives that might have similar cognitive or stress-modulating effects. Thanks a lot, and really appreciate your work.
I’mCAN I PLEASE CALL YOU?! having technology issues. I suddenly got my vision back tonight! I’m not blind . I had exceptional vision until I did not. I was in my late forties when I started having double vision. I thought it was just fatigue, but when it wouldn’t go away with rest I went to an optometrist. They said I was far sighted with a little astigmatism
Women and fasting (and metabolism and longevity)
You've already had David Sinclair on it appears (first episode! )but I found his book Lifespan to be so interesting on topics not obvious when we talk about the future of longevity; namely the effects on society, demography and politics and--more specifically here--how medical research funding incentivizes researchers to avoid hormonal complications to achieve "cleaner results" by excluding females. He perhaps merits another interview :) On that note, fasting over 24h provokes painful uterine contractions and an off-cycle period for me yet I've never found a good study to better understand why. I've heard that HPAA disruption in women is common when fasting and that I should wait until after menopause to try fasting. Is this true ? What about differences for other longevity protocols ? Love the show, I discovered H Lab through your interview on The Drive and I'm wondering when the Ben Barres memoirs will come out? What a moving episode, thank you for sharing! -Sydney
Stopping Sugar Trizipitide
I am 68 year old woman and in pretty good shape. I lift weights, swim and cycle. I have lots of sugar cravings and have been a sugar fiend all my life. How can I change this? Also what do you think of microdosing Trizipetide to help inflamation and lose a few pounds?
NAD+ Boosting - longevity benefits v. potential tumorigenic effects
In your October 30 podcast, The Biology of Slowing & Reversing Aging with Dr. David Sinclair you discuss the cellular and molecular mechanisms of aging—and how specific behaviors, such as fasting, regular exercise and NAD⁺-boosting compounds like NMN, can activate the body’s natural longevity pathways. Dr. Sinclair explains that he takes 1 gram of NMN a day to boost NAD+. But there is a body of research that suggests that boosting NAD+ and those same pathways can support the metabolic and survival demands of pre-existing cancer cells, potentially enhancing tumor growth or resistance to stress and therapy. Targeting NAD+ metabolism: dual roles in cancer treatment Jiaxin Yong et al. Front Immunol. 2023. Nicotinamide Adenine Dinucleotide (NAD) Metabolism as a Relevant Target in Cancer by Lola E. Navas 1,2 and Amancio Carnero (2022) I would be extremely curious to get your and Dr. Sinclair’s view on this. And thank you for the amazing podcasts! Keep them coming.
Over 60 Tips on Protein Consumption VS Benefits of Time Restricted Eating
I particularly enjoyed the podcast relating to mistakes that seniors over 60 years of age might make in their mornings. I implemented a number of the suggestions and feel that they made a big improvement in my general well-being. Recently, I listened to the podcast on the benefits of time restricted eating. I am 65 and very fit and healthy. Would it be best for me to continue having 25 to 30 g of protein within an hour of waking in the morning as well as the 25 g of protein one hour before bed suggested in the over 60 podcast as opposed to the suggested 10:00 am to 6:30 pm feeding window? I regularly exercise incorporating resistance training and so your tips about avoiding sarcopenia are very important to me. I also was having leg pain in the night that has stopped since I increased my protein intake. Thank you for your sharing of such great information1
Chronic Inflammation, Atherosclerosis & Brain Health
There’s seems to be a growing evidence that atherosclerosis and arterial plaque are not just driven by elevated LDL, but also by chronic low-grade inflammation. What does the latest science say about this connection between silent inflammation and plaque formation or progression? How strong is the evidence linking silent inflammation to plaque formation and progression — and potentially also to neurodegenerative diseases like Alzheimer’s? What are the most promising evidence-based interventions to lower systemic inflammation and protect vascular health — beyond simply reducing LDL? And a full episode on this topic would be fantastic!
Strengthen the immune system
Andrew, what does the current research say about how we can strengthen the immune system as we age—especially for people over 50? Beyond peptides, what are the most promising approaches in terms of supplementation, nutrition, or lifestyle interventions? For example, are there interesting findings around maintaining NAD levels or other cellular resilience strategies that actually translate into measurable immune benefits? And since you’re also approaching that magic 5-0, I’m curious — what’s your own personal routine when you feel a cold or flu coming on? How do you get back on track quickly?