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Guest Suggestion: Dr. Mark Mattson

It would be great for Dr. Huberman to have Dr. Mark Mattson on the podcast. https://www.youtube.com/watch?v=dhjZcFbKFdM Dr. Mark Mattson is an adjunct professor of neuroscience at the Johns Hopkins University School of Medicine and the former chief of the Neuroscience Research Laboratory at the National Institute on Aging. He is one of the most cited neuroscientists in the world, with more than 180,000 citations of his work noted in the scientific literature. Dr. Mattson's rigorous work has advanced scientific understanding of brain aging and identified fundamental aspects of age-related neurodegenerative disorders, including Alzheimer’s disease and Parkinson’s disease. His most notable work has focused on how the brain responds to mild stressors, such as those associated with exercise and intermittent fasting.

Fat coffe and time-restricted feeding

Does fat-coffee (also known as bulletproof coffee) break the fast when I drink it outside my feeding window?

failure in tests, pain, giving up

What happens in the brain when a student, after failing tests and exams, is unable to return to study due to pain? They want to go back to study, but the body reacts with symptoms that look like anxiety. What happens? Could it be that the brain recorded failure as a negative emotional valence marking and studying became a pain trigger?

Biochemistry of Hate, Revenge

From the podcast with Lex Fridman. "people can't give up hate, it's like a drug". What's the evolutionary value of hate? What's the biochemistry of hate and revenge? In her book Between Us (it's about emotions), she refers to Inuit peoples' culture as not tolerating anger since it is actually dangerous to the integrity of the group. I'm a counsellor, and I would like to be better at helping people let go of hate and revenge. Understand some of the biology of this could be useful. Thanks for your great work. Fridman was a great podcast!

Topical Finasteride Side Effects

You’ve mentioned the potential downsides of taking oral finasteride due to the effects of lowered DHT. Do the same risks apply to topical finasteride, or is the topical formula more localized compared to the systemic effect of the oral version?