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How to know what advice is 'the best' advice

A slightly off-center question but how I/we know what so-called science-based advice to trust given the vast amount of conflicting protocols, suggestions, tools, and ways of life (i.e carnivore vs vegan die). What is the best way to approach the literature of not just scientific articles but social media posts, varying podcasts, and other forms of information sources? Thanks

Is there any medicament to revert the symptom of an extremely long time, or even unateinable, to reach ejaculation, after many years of a continuos treatement with an antidepressant drug like oxalate of escitalopram?

We have recently celebrated, at the age of 78, our 54th wedding anniversary, and we still have an active sexual life. Unfortunately, after many years having to continuously take an antidepressant ( oxalate of escitalopram) I have been experimenting an almost unattainable ejaculation which has been very frustrating for me. That's why my question if there is any medication to revert that, since I can not yet reduce the daily 15 mg of the antidepressant I have to take.

Which is the most recent kown treatment to contain, or reverse, the deleterial progress of a (MSA) Multiple Systema Atrophy desease.

One of my friends and former university coleague, now aging around 78, has been suffering of a deasase diagnosed as (MSA) Multiple System Atrophy, which is now keeping him without any movements, not even allowing him to speak. However his mind is still quite alive and he understands everything.I recently visited him in the nursing home were his is now, and had the cahnce of interacting with him, talk and remember our time at the university, and I could see some smilles slightly showing up in his face. I decided to ask this question to see if there could be any new information available in order to help him.

UNDER-NOURISHMENT SIDE EFFECT

There is plenty of information about the side effect of overnourishment and obesity. But it is very rare to find information about the negative effects on body and mind of a state in which the body is starved and/or lack of fat tissue. I think this might be interesting as far as all major longevity experts underline the problem of eating to much. This might lead to the other side of the balance. So the question: when is eating too little/being underfed damaging <<healthspan>> and by which meachanisms does it do so?

Which are the most updated treatment to mitigate the effects of a DUPUYTREN`S CONTRACTURE desease?

One of my cousin brothers has been suffreing for the past 20 years of a disease that was diagnosed as being Dupuytren`sContracture. It started sudenly when he has undergone an appendicitis surgery. When leaving the surgical room he had a lump and a bending finger is his left hand, Before his hand was absolutely normal. Along these years the contracture progressed, he had a surgery , but with no great improvements, and now he is trying a therapy with shock waves and big stretches, which seems to be providing some help. After a while the contractures had span to the right hand. Is there any new treatment known to this desease?