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Caloric restriction in fertile women?

Hi - I know we hear about the benefits of caloric restriction for lifespan/telomeres etc. But I wonder how that applies to women in their fertile years. Anecdotally, I've seen many cases of young women losing their cycle while undereating or dieting. I have also seen some (contested?) data that says intermittent fasting is not the best idea for women preparing to conceive. I'd love to hear more about healthspan data in the context of women's hormonal health (though I'm sure that can get convoluted!).

Potential risks of Bluetooth earbuds ?

Hi Andrew ! I’d love to know your read of the literature on potential risks of heavy use of wireless earbuds. You mentioned recently that you use wired headphones which led me to suspect that you have some reason to avoid wireless earbuds. (I wear Bluetooth earbuds up to 10 hours per day. I find it helps me to focus on tasks.) P.S. Thank you for your work to share science with the public. I’ve been listening since episode #1, and t what I’ve learned has empowered me to leverage myself out of chronic sleep and mood disorders. Life changing !

When will you do an episode on migraine treatments?

I have several friends that suffer from chronic migraines and seem to have trouble finding effective treatment.

Effects of Social Isolation

Is there any research that goes into depth on the effects of social isolation and loneliness? I know you talked about tachykinin in the past but I'm wondering if people that are shut-ins for very long periods of time undergo neurologic changes that make it very difficult for them to assimilate back into society.

How do you use Ultradian Cycles in your daily work?

You've mentioned before that you try to include at least 1 90 minute focus block per day as part of your work and overall mission. What is your max number of blocks you can perform sustainably? Do you take vacations or extended breaks? If you knew you needed to drastically increase the amount of focus you do daily, how would you schedule that focus and recover from it? Thank YOU for your interest in science!