Cold exposure question
Is exposure to cold air (northern, winter climates) worse/better than cold exposure in water? I assume they are different. How do you calcuate the difference if you don't have access to a cold plunge but live in a cold climate and could just use the outdoors shirtless for example.
Vaccine Injuries
Can you talk about why some people are injured by vaccines and others are not? Is there some kind of genetic predisposition that determines how the body will respond to a vaccine? In some recent vaccines there have been some clear trends emerging with injuries like trigeminal neuralgia, myocarditis, bell's palsy, etc. that will occur in some but not others, even from the same batch of the drug. Would love to better understand the science on this one.
STI
Can you do a podcast about recent research around STI‘s, treatments/innovations and why some are still not curable? e.g. San Francisco had seen has seen a new strain of chlamydia that is not treatable by antibiotics, herpes is treatable, but not curable, the many strains of HPV (some of which can be prevented with a vaccine)…
Are you familiar with the supplement: Paraxanthine
I've heard a health/workout podcast recommend the supplement "paraxanthine" as a caffeine substitute, saying it has most of the benefits without interfering with sleep if used later in the day. Curious what you know/think about it. Examine.com has no information. From ChatGPT: Paraxanthine, also known as 1,7-dimethylxanthine, is a metabolite of caffeine. It is formed in the human body as caffeine is metabolized. When you consume caffeine through sources like coffee, tea, or energy drinks, your body processes it into several different compounds, and paraxanthine is one of them. Paraxanthine has stimulant effects similar to caffeine, but it's generally less potent. It contributes to some of the physiological effects associated with caffeine consumption, such as increased heart rate, alertness, and improved cognitive performance. Caffeine is metabolized in the liver by enzymes belonging to the cytochrome P450 family, leading to the formation of paraxanthine, theobromine, and theophylline. These metabolites can have various effects on the body and contribute to the overall experience of consuming caffeine-containing beverages and foods.