Exact behavior of dopamine Excluding hard & illegal drugs from the picture, why are dopamine peaks so bad if dopamine always goes up and then below baseline no matter what? Is dopamine over/below baseline always symmetrical -- i.e. equal and opposite and equivalent duration effects? If that's the case then pursuing things that stretch dopamine increase over hours/days might also be a bad idea, in some cases worse than some short-term drugs perhaps. So what is the exact behavior of dopamine in all such contexts?
Hi Dr. Huberman - My Dad has been a long sufferer of a movement disorder that is in part Small Vessell Disease (Atherosclerosis) of the Brain and Atypical Parkinsonism. I'm wondering if the Huberman Lab Nation would benefit from what one can do in their 30's, 40's, and 50's to help combat the genetic predisposition they've been dealt. In other words, what could I do, if anything, to alter a similar path to what my father is going thru in his late 70's? Are there proactive strategies, supplementation, exercise and or mental regimes one could participate in during these early decades? I believe the answer to this topic would be helpful for other neurodegenerative disorders of the brain and the listeners currently being affected by this. Thank You for all that you do Dr. Huberman; we are so grateful for your passion and purpose.
I have heard on other YouTube videos and podcasts that cold exposure can help to reduce cortisol. However, you did not mention this on your podcast. You only stated that catecholamines could be increased without any associated increase in cortisol. Could you revisit the relationship between cold exposure and cortisol? Is there any potential to use cold exposure to decrease cortisol?