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Hormones after Menopause

Hi, I am 56 and have been taking bio identical hormones for 3 yrs after being post meno for 4 yrs. I have regular cycles feel healthy, sleep well lost weight. I heard on David Sinclair podcast you mentioned that we are using up our vitality by doing this. Can you expand on this in anyway? I was so unwell before so I would choose to die sooner with a better quality of life than to age naturally with all the pain that comes with that. Thank you

Strength vs hypertrophy, calisthenic vs gym

My understanding is that doing resistance training with higher weight and not many repetitions (3 to 5) increases mainly the strength but lowering the weights and doing more repetitions increases the muscle hypertrophy. If that’s correct, why is it that people practicing calisthenics are not that big, they don’t develop much hypertrophy but they are known to be very strong? In calisthenics you reach a point in which you cannot move heavier weights as you work with your body so you can only increase repetitions. I might be wrong and ask a silly question, by the way.

Derealization and Depersonalization

Why do we develop these symptoms? Are they a symptom of an overall anxiety? Finally can it be turned off?

Raynaud's phenomenon and cold exposure

I am a thin-yet-fit 61yo woman, chill very easily, and have had Raynaud's phenomenon since my early 20s. I have been advised to stay warm to ward off arterial spasm in my fingers, which happens very easily, so I use the sauna but not cold plunge. I'm wondering if I should try not only using cold shower water for a minute or two after warm water, but a modified plunge (short, shallow, not-too-cold) in an attempt to increase brown fat and perhaps reduce episodes of vasospasm, or if I should simply stay away from that much cold exposure. The underlying question is: Can I do anything to mitigate Raynaud's phenomenon using heat and cold exposure? Many thanks!

Cardio Vascular health

What specific protocols and behaviors could help with heart health improving lipids and lowering triglycerides etc and what kind of supplements could help improve cardio health