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insulin and the nervous system

Please can you explain the relationship between insulin and the nervous system (in particular high insulin and sympathetic dominance)? Thank you.

about time…

Why is it that when we do something we love - we “lose” time, or feel we don’t have enough of it? Whereas when we are engaged in something we do not want to do - time goes on forever? How does our relationship with/perception of time change as we age (e.g. as a child school holidays feel as if they go on forever, but for an adult vacation is over so quickly)? Can we stretch time - to have more of it (perceptually)? If we mentally (connect old with memories) go back in time does that have a “youthing” effect (e.g. listen to music from adolescence or watch movies from that time)? How can we make the most of the time we have? Thanks kindly.

laughter and dopamine

I am curious to know if addiction can stop/reduce our ability to laugh. Is this related to dopamine in some way? If so, what is the neuroscience behind that phenomenon? I recently gave something up and (funnily enough) found myself re-engaged with laughter (which I didn’t even know I had lost until it came back again). Thanks!

Physical health tests

I'm a 37 y.o. man, fit and relatively healthy with history of ankylosing spondylitis in recession. I'd like to ask for an advice for a set of blood tests that I can just do at the local diagnostic lab (hemo testing lab or something similar). By the way I leave in areas of the world where there's no sun during winter periods. I want to do a complete body screening. There's suggestion from AI to do the following tests. Would you add/change anything or maybe steer attention to a certain markers? Blood Tests Complete Blood Count (CBC): Evaluates overall health and detects a variety of disorders, including anemia, infection, and many other diseases. Lipid Profile: Assesses the risk of developing cardiovascular diseases by measuring cholesterol levels, including LDL, HDL, and triglycerides. Blood Glucose Tests: Measures blood sugar levels to check for diabetes or pre-diabetes. Liver Function Tests: Assesses the health of the liver by measuring enzymes, proteins, and substances produced or cleared by the liver. Renal (Kidney) Function Panel: Evaluates kidney function through various parameters like creatinine, BUN (Blood Urea Nitrogen), and electrolyte levels. Thyroid Function Tests: Includes TSH, T3, and T4 tests to assess thyroid gland function. Electrolyte Panel: Measures electrolytes such as sodium, potassium, chloride, and bicarbonate; important for assessing heart and kidney health. Vitamin and Mineral Levels: Including Vitamin D, B12, iron, calcium, and others as relevant. Inflammatory Markers: Such as C-reactive protein (CRP) and ESR (Erythrocyte Sedimentation Rate), which can indicate inflammation in the body. Hormone Tests: Depending on symptoms, tests like estrogen, testosterone, cortisol, etc., can be considered. Coagulation Panel: Tests like PT, INR, and aPTT, which assess blood clotting. Urine Tests Urinalysis: A common test that checks the appearance, concentration, and content of urine. It's used to detect a range of disorders, such as urinary tract infections, kidney disease, and diabetes. Microalbuminuria and Creatinine: These tests check for small amounts of protein in urine, an early sign of kidney damage.

Impacts caused by COVID on resting heart rate/HRV

Wondered whether there is anything recent known about. Thanks very much for sharing insights.