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Synaptopathy

Is it an idea to invite Karl Friston on the show to talk about synaptopathy and psychopathology, and challenging him to also relate daily applications of these concepts?

Glutamine Glutamate cycle

Could you please explain the Glutamine Glutamate cycle in relation to the brain rather than exercise. Thank you in advance.

Does too much sleep cause depression?

My experience is that when I sleep a lot (more than 8 hours) I start to feel really down/heavy/bad thoughts. I know how much you stress getting enough sleep, but is there anything you can speak to about too much sleep? I realize this might be a chicken-egg thing - maybe the reason I've been wanting to sleep more is the lack of motivation/drive that causes the heaviness. But have always been curious about this relationship. Perhaps a better question is: What happens to the brain when we sleep more than 8 hours? Thank you for your interest in humanity Dr Huberman! Love, Ellen

Tyrosine supplementation increases appetite.

I'm ADHD and otherwise unmedicated until my perimenopause settles down along with other untoward side effects (Vyvanse induced hypertension). I've been trialling Tyrosine and it does seem to have some effect on perceived stress and is making a mundane work choice bearable. It doesn't however help with studying as it makes me quite sleepy, but more interestingly, it makes me very hungry! It almost feels like it lessens my already low impulse control as I find myself continually reaching for something to eat and unable to stop myself. I'm aware of some research done in anorexic mice but as a healthy weight female human I'm just wondering what may be happening to cause such an increase in appetite.

Efficacy of chiropractor techniques

Can you do an episode on the general field of chiropractors? For me this question derives from my wife having Meniere's Disease and finding some compelling indications of the value of upper cervical (atlas) realignment. At the same time I was taught early in life to mistrust the chiropractor industry. I can't help hoping this is a bit like acupuncture. Misunderstood. Some number of quacks. But perhaps a valid basis underneath?